2021 schedule
Michigan State
Big Ten
Final rank
#8
Record
10-2
Points
31
Diff
+75
Scored
383
Allowed
308
Outcome
—
Game log
Real CFBD regular-season results. Points earned per game follow the opponent's 2021 starting tier: 5 for Tier 1, 4 for Tier 2, 3 for Tier 3, 2 for Tier 4, 1 for Tier 5, 0 for FBS losses or FCS wins, and −3 for any loss to an FCS opponent.
| Week | Opponent | Site | Score | Result | Pts |
|---|---|---|---|---|---|
| 2 | Northwestern(Tier 2) | Away | 38 – 21 | W | +4 |
| 3 | FCS opponent | Home | 42 – 14 | W | 0 |
| 4 | Miami (FL)(Premier) | Away | 38 – 17 | W | +5 |
| 5 | Nebraska(Tier 2) | Home | 23 – 20 | W | +4 |
| 6 | Western Kentucky(Tier 4) | Home | 48 – 31 | W | +2 |
| 7 | Rutgers(Tier 5) | Away | 31 – 13 | W | +1 |
| 8 | Indiana(Tier 2) | Away | 20 – 15 | W | +4 |
| 10 | Michigan(Tier 2) | Home | 37 – 33 | W | +4 |
| 11 | Purdue(Tier 4) | Away | 29 – 40 | L | 0 |
| 12 | Maryland(Tier 4) | Home | 40 – 21 | W | +2 |
| 13 | Ohio State(Premier) | Away | 7 – 56 | L | 0 |
| 14 | Penn State(Premier) | Home | 30 – 27 | W | +5 |
