2021 schedule
Louisville
CUSA
Final rank
#13
Record
6-6
Points
18
Diff
+59
Scored
383
Allowed
324
Outcome
—
Game log
Real CFBD regular-season results. Points earned per game follow the opponent's 2021 starting tier: 5 for Tier 1, 4 for Tier 2, 3 for Tier 3, 2 for Tier 4, 1 for Tier 5, 0 for FBS losses or FCS wins, and −3 for any loss to an FCS opponent.
| Week | Opponent | Site | Score | Result | Pts |
|---|---|---|---|---|---|
| 2 | Ole Miss(Tier 3) | Away | 24 – 43 | L | 0 |
| 3 | FCS opponent | Home | 30 – 3 | W | 0 |
| 4 | UCF(Premier) | Home | 42 – 35 | W | +5 |
| 5 | Florida State(Tier 2) | Away | 31 – 23 | W | +4 |
| 6 | Wake Forest(Tier 4) | Away | 34 – 37 | L | 0 |
| 7 | Virginia(Tier 3) | Home | 33 – 34 | L | 0 |
| 9 | Boston College(Tier 3) | Home | 28 – 14 | W | +3 |
| 10 | NC State(Tier 3) | Away | 13 – 28 | L | 0 |
| 11 | Clemson(Premier) | Home | 24 – 30 | L | 0 |
| 12 | Syracuse(Tier 3) | Home | 41 – 3 | W | +3 |
| 13 | Duke(Tier 3) | Away | 62 – 22 | W | +3 |
| 14 | Kentucky(Tier 3) | Home | 21 – 52 | L | 0 |
